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COL6A3 has not been detected as a mutational cancer driver

COL6A3
Ensembl id ENSG00000163359
Mutated samples
Coding Sequence 327 (4.8%)
Protein Affecting 232 (3.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all COL6A3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 88 55 14.91
Lung adenocarcinoma No 33 29 7.42
Breast carcinoma No 23 18 1.57
Stomach adenocarcinoma No 25 17 10.56
Glioblastoma multiforme No 20 16 4.22
Head and neck squamous cell carcinoma No 24 15 4.00
Colorectal adenocarcinoma No 17 14 6.11
Lung squamous cell carcinoma No 13 10 5.75
Serous ovarian adenocarcinoma No 12 10 3.16
Renal clear cell carcinoma No 13 9 2.16
Bladder carcinoma No 7 6 6.12
Uterine corpus endometrioid carcinoma No 9 5 2.17
Lower grade glioma No 6 5 2.96
Small cell lung carcinoma No 5 5 7.25
Esophageal carcinoma No 7 5 3.42
Prostate adenocarcinoma No 6 4 1.65
Pancreas adenocarcinoma No 2 2 0.93
Thyroid carcinoma No 3 2 0.62
Multiple myeloma No 2 2 2.90
Hepatocarcinoma No 5 1 1.11
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 2 1 0.34
Non small cell lung carcinoma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence