IntOGen - COL2A1 gene cancer mutations

COL2A1 is detected as a mutational cancer driver

COL2A1 reports

Methods
Mutation distribution

Gene details

COL2A1
Ensembl ID ENSG00000139219 Transcript ID ENST00000380518 Protein ID ENSP00000369889
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 3 Mutations 768
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence