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CLSTN2 has not been detected as a mutational cancer driver

CLSTN2
Ensembl id ENSG00000158258
Mutated samples
Coding Sequence 175 (2.6%)
Protein Affecting 116 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CLSTN2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 43 31 8.40
Head and neck squamous cell carcinoma No 24 18 4.80
Lung squamous cell carcinoma No 18 17 9.77
Lung adenocarcinoma No 14 11 2.81
Breast carcinoma No 10 6 0.52
Colorectal adenocarcinoma No 6 6 2.62
Renal clear cell carcinoma No 5 5 1.20
Esophageal carcinoma No 8 5 3.42
Stomach adenocarcinoma No 7 3 1.86
Small cell lung carcinoma No 3 3 4.35
Glioblastoma multiforme No 5 3 0.79
Prostate adenocarcinoma No 2 2 0.82
Uterine corpus endometrioid carcinoma No 3 2 0.87
Non small cell lung carcinoma No 2 2 6.45
Bladder carcinoma No 2 1 1.02
Pancreas adenocarcinoma No 2 1 0.47
Hepatocarcinoma No 3 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 14 0 0.00
Pylocytic astrocytoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence