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CLCN3 has not been detected as a mutational cancer driver

CLCN3
Ensembl id ENSG00000109572
Mutated samples
Coding Sequence 50 (0.7%)
Protein Affecting 43 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CLCN3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 12 11 2.98
Breast carcinoma No 7 6 0.52
Head and neck squamous cell carcinoma No 4 4 1.07
Lung adenocarcinoma No 5 3 0.77
Lung squamous cell carcinoma No 3 3 1.72
Uterine corpus endometrioid carcinoma No 3 3 1.30
Renal clear cell carcinoma No 2 2 0.48
Thyroid carcinoma No 2 2 0.62
Stomach adenocarcinoma No 3 2 1.24
Prostate adenocarcinoma No 1 1 0.41
Neuroblastoma No 1 1 0.48
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 1 1 0.68
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence