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CHRM3 has not been detected as a mutational cancer driver

CHRM3
Ensembl id ENSG00000133019
Mutated samples
Coding Sequence 133 (2.0%)
Protein Affecting 75 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CHRM3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 43 26 7.05
Lung adenocarcinoma No 15 12 3.07
Stomach adenocarcinoma No 7 6 3.73
Head and neck squamous cell carcinoma No 8 6 1.60
Bladder carcinoma No 4 4 4.08
Breast carcinoma No 5 3 0.26
Lung squamous cell carcinoma No 3 3 1.72
Uterine corpus endometrioid carcinoma No 4 3 1.30
Serous ovarian adenocarcinoma No 4 3 0.95
Renal clear cell carcinoma No 2 2 0.48
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 20 1 0.34
Glioblastoma multiforme No 2 1 0.26
Hepatocarcinoma No 6 0 0.00
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence