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CHL1 has not been detected as a mutational cancer driver

CHL1
Ensembl id ENSG00000134121
Mutated samples
Coding Sequence 157 (2.3%)
Protein Affecting 118 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CHL1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 44 34 9.21
Lung adenocarcinoma No 20 15 3.84
Uterine corpus endometrioid carcinoma No 11 9 3.91
Stomach adenocarcinoma No 13 9 5.59
Glioblastoma multiforme No 8 8 2.11
Esophageal carcinoma No 8 7 4.79
Colorectal adenocarcinoma No 7 6 2.62
Bladder carcinoma No 6 5 5.10
Lung squamous cell carcinoma No 5 5 2.87
Head and neck squamous cell carcinoma No 6 5 1.33
Prostate adenocarcinoma No 3 3 1.23
Renal clear cell carcinoma No 3 3 0.72
Small cell lung carcinoma No 3 3 4.35
Hepatocarcinoma No 5 2 2.22
Breast carcinoma No 5 2 0.17
Neuroblastoma No 2 1 0.48
Serous ovarian adenocarcinoma No 1 1 0.32
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 5 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence