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CHEK2 has not been detected as a mutational cancer driver in this cancer type

Neuroblastoma
Projects 1
210 Samples
Coding sequence mutations (CSMs)
in driver genes 92
in all genes 7150
Protein affecting mutations (PAMs)
in driver genes 87
in all genes 3973
CHEK2
Ensembl id ENSG00000183765
Mutated samples
Coding Sequence 1 (0.5%)
Protein Affecting 1 (0.5%)
Mode of action Loss of function
Known driver Yes
Project Signals
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Neuroblastoma projects in all CHEK2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Neuroblastoma Broad obtained from AlexandrovEtAl No 1 1 0.48
The mutations needle plot shows the distribution of the observed CHEK2 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification