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CFHR2 has not been detected as a mutational cancer driver

CFHR2
Ensembl id ENSG00000080910
Mutated samples
Coding Sequence 176 (2.6%)
Protein Affecting 44 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CFHR2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 66 16 4.34
Head and neck squamous cell carcinoma No 15 5 1.33
Lung adenocarcinoma No 15 3 0.77
Lung squamous cell carcinoma No 15 3 1.72
Uterine corpus endometrioid carcinoma No 6 3 1.30
Esophageal carcinoma No 10 3 2.05
Bladder carcinoma No 4 2 2.04
Stomach adenocarcinoma No 9 2 1.24
Acute myeloid leukemia No 1 1 0.51
Breast carcinoma No 11 1 0.09
Renal clear cell carcinoma No 5 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 3 1 1.45
Glioblastoma multiforme No 6 1 0.26
Hepatocarcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence