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CFH has not been detected as a mutational cancer driver

CFH
Ensembl id ENSG00000000971
Mutated samples
Coding Sequence 199 (2.9%)
Protein Affecting 158 (2.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CFH gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 56 41 11.11
Lung adenocarcinoma No 21 19 4.86
Breast carcinoma No 19 16 1.39
Esophageal carcinoma No 18 14 9.59
Stomach adenocarcinoma No 13 13 8.07
Head and neck squamous cell carcinoma No 12 10 2.67
Bladder carcinoma No 8 7 7.14
Lung squamous cell carcinoma No 6 6 3.45
Uterine corpus endometrioid carcinoma No 8 6 2.61
Prostate adenocarcinoma No 7 5 2.06
Renal clear cell carcinoma No 4 4 0.96
Colorectal adenocarcinoma No 5 4 1.75
Chronic lymphocytic leukemia No 3 2 0.69
Lower grade glioma No 3 2 1.18
Small cell lung carcinoma No 3 2 2.90
Glioblastoma multiforme No 2 2 0.53
Hepatocarcinoma No 2 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 3 1 3.23
Multiple myeloma No 1 1 1.45
Thyroid carcinoma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence