Top
CDKN2A is detected as a mutational cancer driver in 1 Lung squamous cell carcinoma project

Lung squamous cell carcinoma
Projects 1
174 Samples
Coding sequence mutations (CSMs)
in driver genes 1013
in all genes 80088
Protein affecting mutations (PAMs)
in driver genes 859
in all genes 43317
CDKN2A
Ensembl id ENSG00000147889
Mutated samples
Coding Sequence 26 (14.9%)
Protein Affecting 26 (14.9%)
Mode of action Loss of function
Known driver Yes
Project Signals
LUSC_TCGA RF
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Lung squamous cell carcinoma projects in all CDKN2A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma TCGA Yes 26 26 14.94
The mutations needle plot shows the distribution of the observed CDKN2A cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification