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CDKN2A is detected as a mutational cancer driver

CDKN2A reports

Gene details
CDKN2A
Ensembl ID ENSG00000147889
Transcript ID ENST00000498124
Protein ID ENSP00000418915
Cancer types where is driver 24
Cohorts where is driver 70
Mutated samples 843
Mutations 1,171
Mode of action Ambiguous
Known driver True
Method signals per Cancer Type
Cancer type Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
In-silico saturation mutagenesis
Alt text
In silico saturation mutagenesis profiles across all tumor types where a specific model is available. Driver mutations (displayed as red dots) are mapped to their positions in the canonical transcript. The dendrogram on the right represents a hierarchical clustering of the profiles based on site-by-site concordance via Matthews Correlation similarity. The track on the top displays the Pfam domains mapping to the canonical transcript. See the FAQs for more details about the in silico saturation mutagenesis computed with boostDM.
Model Mutations Driver mutations Driver mutations (%)
HNSC (Head and Neck Squamous Cell Carcinoma) 1494 270 18.07
LUNG_CANCER (Lung) 1494 231 15.46
LUSC (Lung Squamous Cell Carcinoma) 1494 270 18.07
CM (Melanoma) 1494 265 17.74
PAAD (Pancreatic Adenocarcinoma) 1494 230 15.39
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Consequence