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CASZ1 has not been detected as a mutational cancer driver

CASZ1
Ensembl id ENSG00000130940
Mutated samples
Coding Sequence 110 (1.6%)
Protein Affecting 76 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CASZ1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 15 4.07
Head and neck squamous cell carcinoma No 10 9 2.40
Breast carcinoma No 7 7 0.61
Lung adenocarcinoma No 8 6 1.53
Prostate adenocarcinoma No 6 5 2.06
Uterine corpus endometrioid carcinoma No 7 5 2.17
Stomach adenocarcinoma No 6 5 3.11
Lung squamous cell carcinoma No 6 4 2.30
Bladder carcinoma No 5 3 3.06
Renal clear cell carcinoma No 3 3 0.72
Colorectal adenocarcinoma No 4 3 1.31
Thyroid carcinoma No 3 2 0.62
Small cell lung carcinoma No 3 2 2.90
Glioblastoma multiforme No 3 2 0.53
Acute myeloid leukemia No 1 1 0.51
Medulloblastoma No 1 1 0.48
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 2 1 0.32
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Esophageal carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence