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CASP8 is detected as a mutational cancer driver in 1 Cutaneous melanoma project

Cutaneous melanoma
Projects 2
369 Samples
Coding sequence mutations (CSMs)
in driver genes 4035
in all genes 413513
Protein affecting mutations (PAMs)
in driver genes 2994
in all genes 167055
CASP8
Ensembl id ENSG00000064012
Mutated samples
Coding Sequence 13 (3.5%)
Protein Affecting 8 (2.2%)
Mode of action Loss of function
Known driver No
Project Signals
CM_TCGA F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Cutaneous melanoma projects in all CASP8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Skin cutaneous melanoma TCGA obtained from Synapse Yes 9 8 2.17
Skin cutaneous melanoma BROAD obtained from Alexandrov No 4 0 0.00
The mutations needle plot shows the distribution of the observed CASP8 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification