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CASP8 is detected as a mutational cancer driver in 2 Breast carcinoma projects and in the PAN-cancer analysis

Breast carcinoma
Projects 6
1148 Samples
Coding sequence mutations (CSMs)
in driver genes 2330
in all genes 84945
Protein affecting mutations (PAMs)
in driver genes 2121
in all genes 45048
CASP8
Ensembl id ENSG00000064012
Mutated samples
Coding Sequence 17 (1.5%)
Protein Affecting 15 (1.3%)
Mode of action Loss of function
Known driver No
Project Signals
BRCA_SANGER F
BRCA_TCGA RF
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Breast carcinoma projects in all CASP8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast invasive carcinoma TCGA Yes 10 10 0.87
Breast Cancer Sanger Institute Yes 3 3 0.26
Triple Negative Breast Cancer UBC Yes 3 2 0.17
Breast cancer BROAD No 1 0 0.00
The mutations needle plot shows the distribution of the observed CASP8 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification