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CAD is detected as a mutational cancer driver in 2 cancer types: Breast carcinoma, Stomach adenocarcinoma and in the PAN-cancer analysis

CAD
Ensembl id ENSG00000084774
Mutated samples
Coding Sequence 146 (2.1%)
Protein Affecting 103 (1.5%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
BRCA F
STAD F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CAD gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 11 9 0.78
Stomach adenocarcinoma Yes 10 9 5.59
Colorectal adenocarcinoma Yes 9 6 2.62
Bladder carcinoma Yes 6 5 5.10
Renal clear cell carcinoma Yes 5 3 0.72
Head and neck squamous cell carcinoma Yes 7 3 0.80
Glioblastoma multiforme Yes 5 3 0.79
Lower grade glioma Yes 4 2 1.18
Cutaneous melanoma No 35 20 5.42
Lung adenocarcinoma No 15 11 2.81
Lung squamous cell carcinoma No 13 10 5.75
Uterine corpus endometrioid carcinoma No 12 9 3.91
Serous ovarian adenocarcinoma No 5 5 1.58
Pancreas adenocarcinoma No 2 2 0.93
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 1 1 1.11
Chronic lymphocytic leukemia No 1 1 0.34
Esophageal carcinoma No 1 1 0.68
Acute myeloid leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence