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CACNA1D has not been detected as a mutational cancer driver

CACNA1D
Ensembl id ENSG00000157388
Mutated samples
Coding Sequence 163 (2.4%)
Protein Affecting 110 (1.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CACNA1D gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 54 27 7.32
Head and neck squamous cell carcinoma No 14 12 3.20
Uterine corpus endometrioid carcinoma No 13 11 4.78
Lung adenocarcinoma No 10 10 2.56
Breast carcinoma No 13 9 0.78
Serous ovarian adenocarcinoma No 6 6 1.90
Stomach adenocarcinoma No 7 6 3.73
Glioblastoma multiforme No 5 5 1.32
Bladder carcinoma No 5 4 4.08
Lung squamous cell carcinoma No 7 4 2.30
Renal clear cell carcinoma No 5 4 0.96
Esophageal carcinoma No 7 3 2.05
Medulloblastoma No 3 2 0.95
Acute lymphocytic leukemia No 2 2 1.64
Prostate adenocarcinoma No 2 1 0.41
Hepatocarcinoma No 2 1 1.11
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 2 1 0.44
Thyroid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence