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BUB1 has not been detected as a mutational cancer driver

BUB1
Ensembl id ENSG00000169679
Mutated samples
Coding Sequence 56 (0.8%)
Protein Affecting 41 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all BUB1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 9 6 1.63
Bladder carcinoma No 5 5 5.10
Lung squamous cell carcinoma No 5 4 2.30
Stomach adenocarcinoma No 5 4 2.48
Lung adenocarcinoma No 4 3 0.77
Head and neck squamous cell carcinoma No 5 3 0.80
Breast carcinoma No 4 2 0.17
Uterine corpus endometrioid carcinoma No 2 2 0.87
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 3 1 0.68
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence