BRCA2 is detected as a mutational cancer driver in Prostate Adenocarcinoma
BRCA2 reports in Prostate Adenocarcinoma (PRAD)
Cancer type details
| Prostate Adenocarcinoma |
|---|
|
Cohorts
13
Samples 2,819 Mutations 9,128,298 Driver genes 104 |
Gene details
| BRCA2 |
|---|
|
Ensembl ID
ENSG00000139618
Transcript ID ENST00000380152 Protein ID ENSP00000369497 |
|
Cohorts where is driver
5
Mutated samples 46 Mutated samples (%) 1.63 Mutations 85 |
| Mode of action Loss of function |
| Known driver True |
Method signals per Cohort
| Cohort | Methods | Samples | Samples (%) |
|---|
ClustL
HotMAPS
smRegions
Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed
mutations along the protein sequence.
| Mutation (GRCh38) | Protein Position | Samples | Samples (%) | Consequence |
|---|