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BRCA2 is detected as a mutational cancer driver in 1 Serous ovarian adenocarcinoma project

Serous ovarian adenocarcinoma
Projects 1
316 Samples
Coding sequence mutations (CSMs)
in driver genes 599
in all genes 26845
Protein affecting mutations (PAMs)
in driver genes 544
in all genes 14718
BRCA2
Ensembl id ENSG00000139618
Mutated samples
Coding Sequence 11 (3.5%)
Protein Affecting 10 (3.2%)
Mode of action Loss of function
Known driver Yes
Project Signals
OV_TCGA F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Serous ovarian adenocarcinoma projects in all BRCA2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Ovarian serous cystadenocarcinoma TCGA Yes 11 10 3.16
The mutations needle plot shows the distribution of the observed BRCA2 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification