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BRCA2 × Lung Squamous Cell Carcinoma ×

BRCA2 is detected as a mutational cancer driver in Lung Squamous Cell Carcinoma

BRCA2 reports in Lung Squamous Cell Carcinoma (LUSC)

Cancer type details
Lung Squamous Cell Carcinoma
Cohorts 6
Samples 703
Mutations 4,282,647
Driver genes 75
Gene details
BRCA2
Ensembl ID ENSG00000139618
Transcript ID ENST00000380152
Protein ID ENSP00000369497
Cohorts where is driver 1
Mutated samples 10
Mutated samples (%) 1.42
Mutations 53
Mode of action Loss of function
Known driver True
Method signals per Cohort
Cohort Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Samples (%) Consequence