IntOGen - BRCA2 gene cancer mutations in BLCA

BRCA2 is detected as a mutational cancer driver in Bladder Urothelial Carcinoma

BRCA2 reports in Bladder Urothelial Carcinoma (BLCA)

Methods
Mutation distribution

Cancer type details

Bladder Urothelial Carcinoma
Cohorts 8 Samples 905 Mutations 6,585,575 Driver genes 89

Gene details

BRCA2
Ensembl ID ENSG00000139618 Transcript ID ENST00000380152 Protein ID ENSP00000369497
Cohorts where is driver 1 Mutated samples 34 Mutated samples (%) 3.76 Mutations 74
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence