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BRCA1 mutations in 1 Glioblastoma multiforme project possibly contribute to the detection of the gene in the PAN-cancer anlaysis:

Glioblastoma multiforme
Projects 2
379 Samples
Coding sequence mutations (CSMs)
in driver genes 842
in all genes 34259
Protein affecting mutations (PAMs)
in driver genes 766
in all genes 17598
BRCA1
Ensembl id ENSG00000012048
Mutated samples
Coding Sequence 3 (0.8%)
Protein Affecting 3 (0.8%)
Mode of action Loss of function
Known driver Yes
Project Signals
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Glioblastoma multiforme projects in all BRCA1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Glioblastoma multiforme TCGA Yes 3 3 0.79
The mutations needle plot shows the distribution of the observed BRCA1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification