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BRAF is detected as a mutational cancer driver in 1 Lung adenocarcinoma project and in the PAN-cancer analysis

Lung adenocarcinoma
Projects 2
391 Samples
Coding sequence mutations (CSMs)
in driver genes 1564
in all genes 112729
Protein affecting mutations (PAMs)
in driver genes 1381
in all genes 61402
BRAF
Ensembl id ENSG00000157764
Mutated samples
Coding Sequence 21 (5.4%)
Protein Affecting 20 (5.1%)
Mode of action Activating
Known driver Yes
Project Signals
LUAD_TCGA RF
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Lung adenocarcinoma projects in all BRAF gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma TCGA Yes 18 17 4.35
Lung adenocarcinoma Washington University Yes 3 3 0.77
The mutations needle plot shows the distribution of the observed BRAF cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification