IntOGen - BIRC3 gene cancer mutations

BIRC3 is detected as a mutational cancer driver

BIRC3 reports

Methods
Mutation distribution

Gene details

BIRC3
Ensembl ID ENSG00000023445 Transcript ID ENST00000263464 Protein ID ENSP00000263464
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 8 Mutations 211
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence