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ATR is detected as a mutational cancer driver in 1 cancer type: Uterine corpus endometrioid carcinoma and in the PAN-cancer analysis

ATR
Ensembl id ENSG00000175054
Mutated samples
Coding Sequence 166 (2.4%)
Protein Affecting 136 (2.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
UCEC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ATR gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma Yes 20 19 5.07
Breast carcinoma Yes 19 18 1.57
Uterine corpus endometrioid carcinoma Yes 17 16 6.96
Small cell lung carcinoma Yes 6 5 7.25
Bladder carcinoma Yes 6 4 4.08
Stomach adenocarcinoma Yes 6 4 2.48
Esophageal carcinoma Yes 4 3 2.05
Serous ovarian adenocarcinoma Yes 2 2 0.63
Cutaneous melanoma No 39 26 7.05
Lung adenocarcinoma No 14 14 3.58
Lung squamous cell carcinoma No 8 7 4.02
Renal clear cell carcinoma No 6 5 1.20
Colorectal adenocarcinoma No 5 4 1.75
Glioblastoma multiforme No 5 4 1.06
Hepatocarcinoma No 2 1 1.11
Thyroid carcinoma No 2 1 0.31
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Diffuse B cell lymphoma No 1 1 4.35
Prostate adenocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence