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ATP2B4 has not been detected as a mutational cancer driver

ATP2B4
Ensembl id ENSG00000058668
Mutated samples
Coding Sequence 80 (1.2%)
Protein Affecting 56 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ATP2B4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 25 15 4.07
Lung adenocarcinoma No 8 6 1.53
Breast carcinoma No 5 5 0.44
Head and neck squamous cell carcinoma No 7 5 1.33
Uterine corpus endometrioid carcinoma No 5 4 1.74
Stomach adenocarcinoma No 4 4 2.48
Prostate adenocarcinoma No 3 3 1.23
Lung squamous cell carcinoma No 4 3 1.72
Small cell lung carcinoma No 3 3 4.35
Bladder carcinoma No 6 2 2.04
Serous ovarian adenocarcinoma No 2 2 0.63
Medulloblastoma No 1 1 0.48
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Colorectal adenocarcinoma No 1 1 0.44
Hepatocarcinoma No 3 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence