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ATP1A4 has not been detected as a mutational cancer driver

ATP1A4
Ensembl id ENSG00000132681
Mutated samples
Coding Sequence 116 (1.7%)
Protein Affecting 82 (1.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ATP1A4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 28 16 4.34
Lung adenocarcinoma No 14 12 3.07
Stomach adenocarcinoma No 13 11 6.83
Breast carcinoma No 13 9 0.78
Uterine corpus endometrioid carcinoma No 7 6 2.61
Lung squamous cell carcinoma No 8 5 2.87
Small cell lung carcinoma No 4 4 5.80
Head and neck squamous cell carcinoma No 8 4 1.07
Renal clear cell carcinoma No 3 3 0.72
Bladder carcinoma No 2 2 2.04
Chronic lymphocytic leukemia No 2 2 0.69
Glioblastoma multiforme No 2 2 0.53
Esophageal carcinoma No 2 2 1.37
Hepatocarcinoma No 4 1 1.11
Thyroid carcinoma No 1 1 0.31
Serous ovarian adenocarcinoma No 2 1 0.32
Colorectal adenocarcinoma No 3 1 0.44
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence