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ATM is detected as a mutational cancer driver in 1 Renal clear cell carcinoma project

Renal clear cell carcinoma
Projects 1
417 Samples
Coding sequence mutations (CSMs)
in driver genes 969
in all genes 41084
Protein affecting mutations (PAMs)
in driver genes 859
in all genes 20546
ATM
Ensembl id ENSG00000149311
Mutated samples
Coding Sequence 13 (3.1%)
Protein Affecting 12 (2.9%)
Mode of action Loss of function
Known driver Yes
Project Signals
RCCC_TCGA F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Renal clear cell carcinoma projects in all ATM gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Kidney clear cell carcinoma TCGA Yes 13 12 2.88
The mutations needle plot shows the distribution of the observed ATM cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification