IntOGen - ATM gene cancer mutations in PAAD

ATM is detected as a mutational cancer driver in Pancreatic Adenocarcinoma

ATM reports in Pancreatic Adenocarcinoma (PAAD)

Methods
Mutation distribution

Cancer type details

Pancreatic Adenocarcinoma
Cohorts 7 Samples 922 Mutations 2,520,434 Driver genes 64

Gene details

ATM
Ensembl ID ENSG00000149311 Transcript ID ENST00000278616 Protein ID ENSP00000278616
Cohorts where is driver 6 Mutated samples 27 Mutated samples (%) 2.93 Mutations 38
Mode of action Ambiguous
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence