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ASH1L mutations in 6 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Hepatocarcinoma, Breast carcinoma, Renal clear cell carcinoma, Serous ovarian adenocarcinoma, Stomach adenocarcinoma, Small cell lung carcinoma

ASH1L
Ensembl id ENSG00000116539
Mutated samples
Coding Sequence 169 (2.5%)
Protein Affecting 124 (1.8%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ASH1L gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 17 11 0.96
Stomach adenocarcinoma Yes 14 11 6.83
Renal clear cell carcinoma Yes 10 3 0.72
Serous ovarian adenocarcinoma Yes 3 3 0.95
Hepatocarcinoma Yes 3 2 2.22
Small cell lung carcinoma Yes 2 2 2.90
Cutaneous melanoma No 37 28 7.59
Lung adenocarcinoma No 17 12 3.07
Uterine corpus endometrioid carcinoma No 12 10 4.35
Bladder carcinoma No 9 7 7.14
Head and neck squamous cell carcinoma No 7 7 1.87
Lung squamous cell carcinoma No 7 6 3.45
Prostate adenocarcinoma No 6 5 2.06
Esophageal carcinoma No 7 5 3.42
Thyroid carcinoma No 4 4 1.24
Colorectal adenocarcinoma No 5 4 1.75
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Glioblastoma multiforme No 2 1 0.26
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence