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ARID1A is detected as a mutational cancer driver in 13 cancer types: Lung adenocarcinoma, Bladder carcinoma, Breast carcinoma, Lung squamous cell carcinoma, Pancreas adenocarcinoma, Renal clear cell carcinoma plus in 7 more and in the PAN-cancer analysis

ARID1A
Ensembl id ENSG00000117713
Mutated samples
Coding Sequence 321 (4.7%)
Protein Affecting 290 (4.3%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
LUAD F
BLCA FR
BRCA F
LUSC F
PAAD F
RCCC F
UCEC FR
CLL F
LGG F
STAD F
COREAD F
DLBC F
ESCA F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ARID1A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma Yes 71 67 29.13
Stomach adenocarcinoma Yes 28 28 17.39
Bladder carcinoma Yes 28 27 27.55
Breast carcinoma Yes 27 26 2.26
Lung adenocarcinoma Yes 14 14 3.58
Lung squamous cell carcinoma Yes 13 12 6.90
Renal clear cell carcinoma Yes 12 12 2.88
Colorectal adenocarcinoma Yes 12 11 4.80
Esophageal carcinoma Yes 12 11 7.53
Lower grade glioma Yes 10 10 5.92
Hepatocarcinoma Yes 10 9 10.00
Chronic lymphocytic leukemia Yes 7 7 2.41
Pancreas adenocarcinoma Yes 5 5 2.34
Medulloblastoma Yes 3 3 1.43
Serous ovarian adenocarcinoma Yes 3 3 0.95
Glioblastoma multiforme Yes 5 3 0.79
Neuroblastoma Yes 2 2 0.95
Small cell lung carcinoma Yes 2 2 2.90
Diffuse B cell lymphoma Yes 2 2 8.70
Cutaneous melanoma No 36 26 7.05
Head and neck squamous cell carcinoma No 14 8 2.13
Acute myeloid leukemia No 1 1 0.51
Acute lymphocytic leukemia No 1 1 0.82
Prostate adenocarcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence