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ARHGEF11 has not been detected as a mutational cancer driver

ARHGEF11
Ensembl id ENSG00000132694
Mutated samples
Coding Sequence 115 (1.7%)
Protein Affecting 84 (1.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ARHGEF11 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 25 6.78
Lung adenocarcinoma No 9 8 2.05
Breast carcinoma No 10 7 0.61
Lung squamous cell carcinoma No 10 7 4.02
Stomach adenocarcinoma No 10 7 4.35
Uterine corpus endometrioid carcinoma No 7 6 2.61
Bladder carcinoma No 3 3 3.06
Pancreas adenocarcinoma No 3 3 1.40
Small cell lung carcinoma No 3 3 4.35
Renal clear cell carcinoma No 2 2 0.48
Serous ovarian adenocarcinoma No 4 2 0.63
Colorectal adenocarcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 4 2 0.53
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Chronic lymphocytic leukemia No 2 1 0.34
Multiple myeloma No 1 1 1.45
Esophageal carcinoma No 2 1 0.68
Medulloblastoma No 3 0 0.00
Neuroblastoma No 2 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence