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ARHGEF10L has not been detected as a mutational cancer driver

ARHGEF10L
Ensembl id ENSG00000074964
Mutated samples
Coding Sequence 90 (1.3%)
Protein Affecting 57 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ARHGEF10L gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 19 10 2.71
Lung adenocarcinoma No 7 6 1.53
Prostate adenocarcinoma No 5 4 1.65
Breast carcinoma No 6 4 0.35
Lung squamous cell carcinoma No 6 4 2.30
Stomach adenocarcinoma No 6 4 2.48
Serous ovarian adenocarcinoma No 5 3 0.95
Small cell lung carcinoma No 3 3 4.35
Colorectal adenocarcinoma No 3 3 1.31
Head and neck squamous cell carcinoma No 4 3 0.80
Bladder carcinoma No 2 2 2.04
Thyroid carcinoma No 2 2 0.62
Uterine corpus endometrioid carcinoma No 3 2 0.87
Lower grade glioma No 2 2 1.18
Hepatocarcinoma No 2 1 1.11
Acute myeloid leukemia No 1 1 0.51
Chronic lymphocytic leukemia No 5 1 0.34
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 2 1 0.68
Pancreas adenocarcinoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence