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APOB has not been detected as a mutational cancer driver

APOB
Ensembl id ENSG00000084674
Mutated samples
Coding Sequence 510 (7.5%)
Protein Affecting 405 (6.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all APOB gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 157 134 36.31
Lung adenocarcinoma No 55 48 12.28
Lung squamous cell carcinoma No 37 26 14.94
Head and neck squamous cell carcinoma No 33 26 6.93
Breast carcinoma No 32 22 1.92
Stomach adenocarcinoma No 25 21 13.04
Esophageal carcinoma No 22 18 12.33
Glioblastoma multiforme No 21 17 4.49
Uterine corpus endometrioid carcinoma No 20 16 6.96
Serous ovarian adenocarcinoma No 15 11 3.48
Colorectal adenocarcinoma No 13 9 3.93
Prostate adenocarcinoma No 11 8 3.29
Renal clear cell carcinoma No 12 8 1.92
Bladder carcinoma No 9 7 7.14
Hepatocarcinoma No 7 5 5.56
Thyroid carcinoma No 5 5 1.55
Lower grade glioma No 9 5 2.96
Small cell lung carcinoma No 7 5 7.25
Neuroblastoma No 5 3 1.43
Acute myeloid leukemia No 2 2 1.02
Medulloblastoma No 3 2 0.95
Pancreas adenocarcinoma No 3 2 0.93
Chronic lymphocytic leukemia No 2 2 0.69
Multiple myeloma No 3 2 2.90
Non small cell lung carcinoma No 1 1 3.23
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence