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APC is detected as a mutational cancer driver in 2 Colorectal adenocarcinoma projects

Colorectal adenocarcinoma
Projects 2
229 Samples
Coding sequence mutations (CSMs)
in driver genes 955
in all genes 29233
Protein affecting mutations (PAMs)
in driver genes 905
in all genes 15873
APC
Ensembl id ENSG00000134982
Mutated samples
Coding Sequence 182 (79.5%)
Protein Affecting 181 (79.0%)
Mode of action Loss of function
Known driver Yes
Project Signals
COREAD_TCGA RFC
COREAD_JHU F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Colorectal adenocarcinoma projects in all APC gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Colorectal adenocarcinoma TCGA Yes 158 158 69.00
Colorectal adenocarcinoma Johns Hopkins University Yes 24 23 10.04
The mutations needle plot shows the distribution of the observed APC cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification