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AP4B1 has not been detected as a mutational cancer driver

AP4B1
Ensembl id ENSG00000134262
Mutated samples
Coding Sequence 52 (0.8%)
Protein Affecting 25 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all AP4B1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Renal clear cell carcinoma No 3 3 0.72
Cutaneous melanoma No 16 3 0.81
Uterine corpus endometrioid carcinoma No 4 3 1.30
Stomach adenocarcinoma No 3 3 1.86
Prostate adenocarcinoma No 2 2 0.82
Lung adenocarcinoma No 3 2 0.51
Serous ovarian adenocarcinoma No 3 2 0.63
Esophageal carcinoma No 3 2 1.37
Bladder carcinoma No 1 1 1.02
Lung squamous cell carcinoma No 2 1 0.57
Small cell lung carcinoma No 1 1 1.45
Head and neck squamous cell carcinoma No 2 1 0.27
Glioblastoma multiforme No 2 1 0.26
Breast carcinoma No 4 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence