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AOX1 has not been detected as a mutational cancer driver

AOX1
Ensembl id ENSG00000138356
Mutated samples
Coding Sequence 131 (1.9%)
Protein Affecting 103 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all AOX1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 39 29 7.86
Lung adenocarcinoma No 15 12 3.07
Lung squamous cell carcinoma No 11 11 6.32
Breast carcinoma No 8 7 0.61
Renal clear cell carcinoma No 7 7 1.68
Small cell lung carcinoma No 6 6 8.70
Serous ovarian adenocarcinoma No 4 4 1.27
Head and neck squamous cell carcinoma No 7 4 1.07
Glioblastoma multiforme No 5 4 1.06
Stomach adenocarcinoma No 5 3 1.86
Prostate adenocarcinoma No 2 2 0.82
Hepatocarcinoma No 3 2 2.22
Bladder carcinoma No 4 2 2.04
Uterine corpus endometrioid carcinoma No 3 2 0.87
Non small cell lung carcinoma No 3 2 6.45
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 2 1 0.31
Neuroblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Esophageal carcinoma No 1 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence