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ANK2 has not been detected as a mutational cancer driver

ANK2
Ensembl id ENSG00000145362
Mutated samples
Coding Sequence 336 (4.9%)
Protein Affecting 256 (3.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ANK2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 64 52 14.09
Lung adenocarcinoma No 52 42 10.74
Lung squamous cell carcinoma No 33 26 14.94
Head and neck squamous cell carcinoma No 32 25 6.67
Colorectal adenocarcinoma No 18 16 6.99
Breast carcinoma No 19 13 1.13
Small cell lung carcinoma No 14 12 17.39
Stomach adenocarcinoma No 17 10 6.21
Renal clear cell carcinoma No 12 9 2.16
Glioblastoma multiforme No 9 9 2.37
Bladder carcinoma No 10 8 8.16
Serous ovarian adenocarcinoma No 7 7 2.22
Uterine corpus endometrioid carcinoma No 8 5 2.17
Chronic lymphocytic leukemia No 10 5 1.72
Prostate adenocarcinoma No 6 4 1.65
Esophageal carcinoma No 6 3 2.05
Hepatocarcinoma No 3 2 2.22
Pancreas adenocarcinoma No 2 2 0.93
Thyroid carcinoma No 2 2 0.62
Acute myeloid leukemia No 2 1 0.51
Medulloblastoma No 4 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Lower grade glioma No 2 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence