Top
ALS2 has not been detected as a mutational cancer driver

ALS2
Ensembl id ENSG00000003393
Mutated samples
Coding Sequence 90 (1.3%)
Protein Affecting 63 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ALS2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 18 4.88
Lung squamous cell carcinoma No 10 9 5.17
Uterine corpus endometrioid carcinoma No 8 7 3.04
Breast carcinoma No 4 4 0.35
Stomach adenocarcinoma No 7 4 2.48
Head and neck squamous cell carcinoma No 7 4 1.07
Lung adenocarcinoma No 3 3 0.77
Renal clear cell carcinoma No 5 3 0.72
Esophageal carcinoma No 3 3 2.05
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 3 1 1.11
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 2 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 2 1 0.34
Colorectal adenocarcinoma No 2 1 0.44
Glioblastoma multiforme No 1 1 0.26
Bladder carcinoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence