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ALK is detected as a mutational cancer driver in Small Cell Lung Cancer

ALK reports in Small Cell Lung Cancer (SCLC)

Cancer type details
Small Cell Lung Cancer
Cohorts 3
Samples 188
Mutations 2,426,920
Driver genes 24
Gene details
ALK
Ensembl ID ENSG00000171094
Transcript ID ENST00000389048
Protein ID ENSP00000373700
Cohorts where is driver 1
Mutated samples 5
Mutated samples (%) 2.66
Mutations 14
Mode of action Activating
Known driver True
Method signals per Cohort
Cohort Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Samples (%) Consequence