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AKR7A2 has not been detected as a mutational cancer driver

AKR7A2
Ensembl id ENSG00000053371
Mutated samples
Coding Sequence 22 (0.3%)
Protein Affecting 19 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all AKR7A2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 6 5 1.36
Lung adenocarcinoma No 2 2 0.51
Stomach adenocarcinoma No 2 2 1.24
Head and neck squamous cell carcinoma No 3 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 1 1 1.11
Acute myeloid leukemia No 1 1 0.51
Uterine corpus endometrioid carcinoma No 2 1 0.43
Multiple myeloma No 1 1 1.45
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 1 1 0.68
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence