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AFF3 has not been detected as a mutational cancer driver

AFF3
Ensembl id ENSG00000144218
Mutated samples
Coding Sequence 151 (2.2%)
Protein Affecting 101 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all AFF3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 34 23 6.23
Head and neck squamous cell carcinoma No 16 13 3.47
Breast carcinoma No 11 10 0.87
Bladder carcinoma No 12 8 8.16
Lung squamous cell carcinoma No 9 7 4.02
Stomach adenocarcinoma No 12 6 3.73
Lung adenocarcinoma No 5 5 1.28
Uterine corpus endometrioid carcinoma No 5 5 2.17
Renal clear cell carcinoma No 7 4 0.96
Colorectal adenocarcinoma No 4 4 1.75
Esophageal carcinoma No 7 4 2.74
Prostate adenocarcinoma No 3 3 1.23
Serous ovarian adenocarcinoma No 3 2 0.63
Small cell lung carcinoma No 2 2 2.90
Medulloblastoma No 3 1 0.48
Pancreas adenocarcinoma No 1 1 0.47
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 2 1 0.59
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
Thyroid carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 6 0 0.00
Pylocytic astrocytoma No 3 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence