IntOGen - AFDN gene cancer mutations

AFDN is detected as a mutational cancer driver

AFDN reports

Methods
Mutation distribution

Gene details

AFDN
Ensembl ID ENSG00000130396 Transcript ID ENST00000366806 Protein ID ENSP00000355771
Cancer types where is driver 2 Cohorts where is driver 4 Mutated samples 27 Mutations 585
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence