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ADRA2B has not been detected as a mutational cancer driver

ADRA2B
Ensembl id ENSG00000222040
Mutated samples
Coding Sequence 37 (0.5%)
Protein Affecting 24 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ADRA2B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 6 6 1.63
Lung squamous cell carcinoma No 5 5 2.87
Serous ovarian adenocarcinoma No 3 3 0.95
Breast carcinoma No 2 2 0.17
Esophageal carcinoma No 5 2 1.37
Lung adenocarcinoma No 2 1 0.26
Hepatocarcinoma No 1 1 1.11
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Head and neck squamous cell carcinoma No 1 1 0.27
Glioblastoma multiforme No 1 1 0.26
Bladder carcinoma No 2 0 0.00
Medulloblastoma No 2 0 0.00
Uterine corpus endometrioid carcinoma No 4 0 0.00
Stomach adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence