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ADCY5 has not been detected as a mutational cancer driver

ADCY5
Ensembl id ENSG00000173175
Mutated samples
Coding Sequence 111 (1.6%)
Protein Affecting 72 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ADCY5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 30 16 4.34
Lung adenocarcinoma No 15 12 3.07
Breast carcinoma No 9 7 0.61
Glioblastoma multiforme No 7 7 1.85
Head and neck squamous cell carcinoma No 9 6 1.60
Uterine corpus endometrioid carcinoma No 5 4 1.74
Stomach adenocarcinoma No 4 4 2.48
Renal clear cell carcinoma No 3 3 0.72
Serous ovarian adenocarcinoma No 4 3 0.95
Esophageal carcinoma No 3 3 2.05
Acute myeloid leukemia No 2 2 1.02
Lung squamous cell carcinoma No 5 2 1.15
Bladder carcinoma No 4 1 1.02
Small cell lung carcinoma No 2 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 4 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence