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ADAMTS4 has not been detected as a mutational cancer driver

ADAMTS4
Ensembl id ENSG00000158859
Mutated samples
Coding Sequence 59 (0.9%)
Protein Affecting 41 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ADAMTS4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 17 8 2.17
Uterine corpus endometrioid carcinoma No 6 6 2.61
Lung adenocarcinoma No 7 5 1.28
Lung squamous cell carcinoma No 5 4 2.30
Serous ovarian adenocarcinoma No 4 4 1.27
Head and neck squamous cell carcinoma No 5 4 1.07
Chronic lymphocytic leukemia No 2 2 0.69
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Lower grade glioma No 1 1 0.59
Stomach adenocarcinoma No 2 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Esophageal carcinoma No 1 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Bladder carcinoma No 1 0 0.00
Breast carcinoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence