IntOGen - ACVR2A gene cancer mutations in STAD

ACVR2A is detected as a mutational cancer driver in Stomach Adenocarcinoma

ACVR2A reports in Stomach Adenocarcinoma (STAD)

Methods
Mutation distribution

Cancer type details

Stomach Adenocarcinoma
Cohorts 6 Samples 858 Mutations 6,723,174 Driver genes 75

Gene details

ACVR2A
Ensembl ID ENSG00000121989 Transcript ID ENST00000241416 Protein ID ENSP00000241416
Cohorts where is driver 1 Mutated samples 8 Mutated samples (%) 0.93 Mutations 31
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence