IntOGen - ACVR2A gene cancer mutations in PAAD

ACVR2A is detected as a mutational cancer driver in Pancreatic Adenocarcinoma

ACVR2A reports in Pancreatic Adenocarcinoma (PAAD)

Methods
Mutation distribution

Cancer type details

Pancreatic Adenocarcinoma
Cohorts 7 Samples 922 Mutations 2,520,434 Driver genes 64

Gene details

ACVR2A
Ensembl ID ENSG00000121989 Transcript ID ENST00000241416 Protein ID ENSP00000241416
Cohorts where is driver 5 Mutated samples 14 Mutated samples (%) 1.52 Mutations 25
Mode of action Ambiguous
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence