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ACVR2A is detected as a mutational cancer driver in 1 cancer type: Stomach adenocarcinoma and in the PAN-cancer analysis

ACVR2A
Ensembl id ENSG00000121989
Mutated samples
Coding Sequence 60 (0.9%)
Protein Affecting 48 (0.7%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
STAD F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ACVR2A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Stomach adenocarcinoma Yes 18 18 11.18
Cutaneous melanoma Yes 5 4 1.08
Hepatocarcinoma Yes 4 3 3.33
Head and neck squamous cell carcinoma Yes 3 3 0.80
Lung adenocarcinoma Yes 2 2 0.51
Breast carcinoma No 5 4 0.35
Colorectal adenocarcinoma No 5 4 1.75
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 1 1 1.02
Lung squamous cell carcinoma No 2 1 0.57
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 3 1 0.24
Thyroid carcinoma No 1 1 0.31
Uterine corpus endometrioid carcinoma No 1 1 0.43
Chronic lymphocytic leukemia No 4 1 0.34
Lower grade glioma No 1 1 0.59
Esophageal carcinoma No 1 1 0.68
Serous ovarian adenocarcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence