IntOGen - ACVR1 gene cancer mutations

ACVR1 is detected as a mutational cancer driver

ACVR1 reports

Methods
Mutation distribution

Gene details

ACVR1
Ensembl ID ENSG00000115170 Transcript ID ENST00000434821 Protein ID ENSP00000405004
Cancer types where is driver 3 Cohorts where is driver 3 Mutated samples 38 Mutations 202
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence